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Submit ReviewTaxol Janelia Fluor® 646
Description: Red-fluorescent taxol derivative. Used for: microtubule staining. Application: confocal microscopy, fluorescence microscopy; protocol available
Chemical Name: 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-4-(((2S)-1-(((2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-diacetoxy-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-4-yl)oxy)-1-oxopropan-2-yl)carbamoyl)benzoate
Purity: ≥95% (HPLC)
Biological Activity for Taxol Janelia Fluor® 646
Key information: Taxol Janelia Fluor® 646 is a red-fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton.
Used for: microtubule cytoskeleton imaging.
Application: confocal microscopy, fluorescence microscopy.
Properties and Photophysical Data: Excitation and emission maxima (λ) are 655 nm and 671 nm, respectively.
For more information on how Taxol-Janelia Fluor® 646 may be used, see our protocol.
Scientific Data
Confocal Microscopy
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Application of Taxol Janelia Fluor® 646, dye on COS7 cells. COS7 cells were labeled with 3 µM Taxol Janelia Fluor® 646 for one hour at 37°C. Images were taken on a Leica TCS SP8 Confocal Laser Scanning Microscope. All images kindly provided by Prof. Christian Soeller, University of Exeter; acquired by Evelina Lucinskaite, Anna Meletiou and Alexander Clowsley.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus
Optical Data for Taxol Janelia Fluor® 646
| Emission Color | Red |
|---|---|
| λabs | 655 nm |
| λem | 671 nm |
| Application | Fluorescence Microscopy, Confocal Microscopy |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for Taxol Janelia Fluor® 646
| M. Wt | 1403.62 |
| Formula | C79H82N4O18Si |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| Smiles | O=C(C)O[C@]12C([C@@]3(C)[C@@H](OC([C@H](C)NC(C4=CC=C(C([O-])=O)C(C5=C(C=C/6)C([Si](C)(C)C7=C5C=CC(N8CCC8)=C7)=CC6=[N+]9CCC\9)=C4)=O)=O)C[C@H]1OC2)[C@H](OC(C%10=CC=CC=C%10)=O)[C@@]%11(O)C(C)(C)C([C@@H](OC(C)=O)C3=O)=C(C)[C@@H](OC([C@H](O)[C@H](C%12=CC=CC=C%12)NC(C%13=CC=CC=C%13)=O)=O)C%11 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Taxol Janelia Fluor® 646
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.07 | 20 |
Preparing Stock Solutions for Taxol Janelia Fluor® 646
The following data is based on the product molecular weight 1403.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 3.56 mL | 17.81 mL | 35.62 mL |
| 1 mM | 0.71 mL | 3.56 mL | 7.12 mL |
| 2 mM | 0.36 mL | 1.78 mL | 3.56 mL |
| 10 mM | 0.07 mL | 0.36 mL | 0.71 mL |
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Product Datasheets for Taxol Janelia Fluor® 646
References for Taxol Janelia Fluor® 646
References are publications that support the biological activity of the product.
If you know of a relevant reference for Taxol Janelia Fluor® 646, please let us know.
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Keywords: Taxol Janelia Fluor 646, Taxol Janelia Fluor 646 supplier, red, fluorescent, taxol, derivative, cytoskeletal, probes, microtubules, fluorogenic, Organelle, and, Cell, Structure, Stains, Microtubule, Probes, 6266, Tocris Bioscience
2 Citations for Taxol Janelia Fluor® 646
Citations are publications that use Tocris products. Selected citations for Taxol Janelia Fluor® 646 include:
Cai et al (2023) Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment. Nat.Commun. 14 4934 PMID: 37582846
Lemaître et al (2021) Capturing T lymphocytes' dynamic interactions with human neural cells using time-lapse microscopy. Front.Immunol. 12 PMID: 33968073
Do you know of a great paper that uses Taxol Janelia Fluor® 646 from Tocris? Please let us know.
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Protocols for Taxol Janelia Fluor® 646
The following protocol features additional information for the use of Taxol Janelia Fluor® 646 (Cat. No. 6266).
Literature in this Area
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*Please note that Tocris will only send literature to established scientific business / institute addresses.
Fluorescent Dyes and Probes Research Product Guide
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