Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTWS 119
Description: Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Purity: ≥97% (HPLC)
Biological Activity for TWS 119
TWS 119 is a potent inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). TWS 119 inhibits both GSK3α and GSK3β in vitro (IC50 = 88 nM and 410 nM, respectively). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells at 400 nM. TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM.
Compound Libraries for TWS 119
TWS 119 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for TWS 119
| M. Wt | 318.33 |
| Formula | C18H14N4O2 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 601514-19-6 |
| PubChem ID | 9549289 |
| InChI Key | VPVLEBIVXZSOMQ-UHFFFAOYSA-N |
| Smiles | OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TWS 119
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.83 | 100 | |
| ethanol | 1.59 | 5 |
Preparing Stock Solutions for TWS 119
The following data is based on the product molecular weight 318.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.71 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for TWS 119
References for TWS 119
References are publications that support the biological activity of the product.
Zeng et al (2009) Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem.Biophys.Res.Commun. 391 1049 PMID: 19995556
Gattinoni et al (2009) Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962
Forget et al (2012) Stimulation of Wnt/β-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype. PLoS One 7 e41074 PMID: 22859966
If you know of a relevant reference for TWS 119, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TWS 119, TWS 119 supplier, TWS119, potent, glycogen, synthase, kinases, inhibitors, neuronal, differentiation, stem, cells, T-cells, tcells, gsk-3, gsk3, gsk-3b, gsk-3beta, gsk-3β, Glycogen, Synthase, Kinase, 3, ESCs, and, iPSC, Neural, Stem, Cells, 7405, Tocris Bioscience
Citations for TWS 119
Citations are publications that use Tocris products.
Currently there are no citations for TWS 119. Do you know of a great paper that uses TWS 119 from Tocris? Please let us know.
Reviews for TWS 119
There are currently no reviews for this product. Be the first to review TWS 119 and earn rewards!
Have you used TWS 119?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for TWS 119
