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Submit ReviewUDP disodium salt
Description: Endogenous ligand; competitive antagonist at P2Y14 receptors
Chemical Name: Uridine-5'-diphosphate disodium salt
Purity: ≥97% (HPLC)
Biological Activity for UDP disodium salt
UDP disodium salt is an endogenous P2Y receptor agonist which preferentially activates P2Y6. Shown to be a competitive antagonist at P2Y14 receptors.
Technical Data for UDP disodium salt
| M. Wt | 448.12 |
| Formula | C9H12N2Na2O12P2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 27821-45-0 |
| PubChem ID | 11957711 |
| InChI Key | ZQKVPFKBNNAXCE-WFIJOQBCSA-L |
| Smiles | [Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N1C=CC(=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UDP disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.81 | 100 |
Preparing Stock Solutions for UDP disodium salt
The following data is based on the product molecular weight 448.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.16 mL | 22.32 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets for UDP disodium salt
References for UDP disodium salt
References are publications that support the biological activity of the product.
Ralevic and Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol.Rev. 50 413 PMID: 9755289
Fricks et al (2008) UDP is a competitive antagonist at the human P2Y14 receptor. J.Pharmacol.Exp.Ther. 325 588 PMID: 18252808
If you know of a relevant reference for UDP disodium salt, please let us know.
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Keywords: UDP disodium salt, UDP disodium salt supplier, Endogenous, ligands, competitive, antagonists, P2Y14, receptors, Purinergic, purinoceptors, P2Y, Receptors, 3111, Tocris Bioscience
2 Citations for UDP disodium salt
Citations are publications that use Tocris products. Selected citations for UDP disodium salt include:
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
Obba et al (2015) The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Alcohol Clin Exp Res 11 1114 PMID: 26029847
Do you know of a great paper that uses UDP disodium salt from Tocris? Please let us know.
Reviews for UDP disodium salt
Average Rating: 5 (Based on 1 Review.)
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P2Y6 activation (P2Y6).
By
Anonymous on 10/22/2018
Assay Type: Ex Vivo
Species: Mouse
Applied directly on a tissue slice to activate P2Y receptors (P2Y6 mostly). Elicited expected cellular response.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.