Upadacitinib

Cat. No. 7783 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: JAK1-selective inhibitor

Chemical Name: (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Upadacitinib

Upadacitinib is a potent and selective JAK1 inhibitor (IC₅₀ = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC₅₀ values are 0.014 μM, 0.593 μM, 1860 μM and 2715 μM). In vivo, Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.

Technical Data for Upadacitinib

M. Wt	380.37
Formula	C₁₇H₁₉F₃N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1310726-60-3
PubChem ID	58557659
InChI Key	WYQFJHHDOKWSHR-MNOVXSKESA-N
Smiles	C(C)[C@H]1[C@@](C=2N3C4=C(N=CC3=NC2)NC=C4)(CN(C(NCC(F)(F)F)=O)C1)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Upadacitinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.04	100
	ethanol	19.02	50

Preparing Stock Solutions for Upadacitinib

The following data is based on the product molecular weight 380.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.15 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for Upadacitinib

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Upadacitinib

References are publications that support the biological activity of the product.

Parmentier et al (2018) In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2 23 PMID: 30886973

If you know of a relevant reference for Upadacitinib, please let us know.

View Related Products by Target

View Related Products by Product Action

View all JAK Inhibitors

Keywords: Upadacitinib, Upadacitinib supplier, Potent, selective, JAK1, JAK2, JAK3, inhibitors, inhibits, janus, kinase, arthritis, in, vivo, JAK, 7783, Tocris Bioscience

Citations for Upadacitinib

Citations are publications that use Tocris products.

Currently there are no citations for Upadacitinib. Do you know of a great paper that uses Upadacitinib from Tocris? Please let us know.

Reviews for Upadacitinib

There are currently no reviews for this product. Be the first to review Upadacitinib and earn rewards!

Have you used Upadacitinib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for Upadacitinib

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.