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YK 4-279

Cat. No. 4067 Submit a Review Datasheet / COA / SDS
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Description: Inhibitor of RNA helicase A (RHA)
Chemical Name: 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for YK 4-279

YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.

Compound Libraries for YK 4-279

YK 4-279 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YK 4-279

M. Wt 366.2
Formula C17H13Cl2NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1037184-44-3
PubChem ID 44632017
InChI Key HLXSCTYHLQHQDJ-UHFFFAOYSA-N
Smiles O=C2NC1=C(Cl)C=CC(Cl)=C1C(CC(C3=CC=C(OC)C=C3)=O)2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for YK 4-279

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.62 100

Preparing Stock Solutions for YK 4-279

The following data is based on the product molecular weight 366.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.31 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for YK 4-279

References are publications that support the biological activity of the product.

Erkizan et al (2009) Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma. Nat.Med. 15 750 PMID: 19584866

If you know of a relevant reference for YK 4-279, please let us know.

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Citations for YK 4-279

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