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ZAP 180013

Cat. No. 6821 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Zap70 inhibitor; inhibits interaction with ITAMs
Chemical Name: 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ZAP 180013

ZAP 180013 is a zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

Compound Libraries for ZAP 180013

ZAP 180013 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ZAP 180013

M. Wt 454.32
Formula C19H17Cl2N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 873080-25-2
PubChem ID 2988718
InChI Key GTWKIPDKVRLUKN-UHFFFAOYSA-N
Smiles O=C(N(CC1=CC=C(Cl)C=C1)CC2=CC=CO2)C3=NC(S(=O)(CC)=O)=NC=C3Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZAP 180013

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.43 100

Preparing Stock Solutions for ZAP 180013

The following data is based on the product molecular weight 454.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.01 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for ZAP 180013

References are publications that support the biological activity of the product.

Visperas et al (2017) Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen. SLAS.Discov. 22 324 PMID: 27932698

If you know of a relevant reference for ZAP 180013, please let us know.

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Citations for ZAP 180013

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