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Nicotinamide

Cat. No. 4106 6 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： PARP-1 inhibitor
化学名： Pyridine-3-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (6)
评论 (1)
实验方案 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Nicotinamide

Nicotinamide is an anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration. Nicotinamide also acts as a SIRT1 inhibitor and promotes the expansion of hematopoietic progenitor cells

Nicotinamide synthesized to Ancillary Material Grade also available.

For more information about how Nicotinamide may be used, see our protocol:

3D Culture of Lung Alveolar Cells

化合物库 for Nicotinamide

Nicotinamide is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Nicotinamide

分子量 122.12
公式 C6H6N2O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 98-92-0
PubChem ID 936
InChI Key DFPAKSUCGFBDDF-UHFFFAOYSA-N
Smiles NC(C1=CC=CN=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nicotinamide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 12.21 100

制备储备液 for Nicotinamide

以下数据基于产品分子量 122.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 8.19 mL 40.94 mL 81.89 mL
5 mM 1.64 mL 8.19 mL 16.38 mL
10 mM 0.82 mL 4.09 mL 8.19 mL
50 mM 0.16 mL 0.82 mL 1.64 mL

Molarity Calculator

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参考文献 for Nicotinamide

参考文献是支持产品生物活性的出版物。

Suzuki et al (2010) Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life.Sci. 86 676 PMID: 20188745

Cimadamore et al (2009) Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 27 1772 PMID: 19544437

Czubak et al (2014) A modified method of Ins producing cells' generation from bone marrow-derived mesenchymal stem cells. J.Diabetes Res. 2014 628591 PMID: 25405207

Sato et al (2015) SnapShot: Growing organoids from stem cells. Cell 161 1700 PMID: 26091044

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: 25307862

Jung et al (2011) Isolation and in vitro expansion of human colonic stem cells. Nat.Med. 17 1227 PMID: 21892181

Boj et al (2015) Organoid models of human and mouse ductal pancreatic cancer. Cell 160 324 PMID: 25557080

Peled et al (2012) Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Exp.Hematol. 40 342 PMID: 22198152

If you know of a relevant reference for Nicotinamide, please let us know.

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关键词: Nicotinamide, Nicotinamide supplier, Nicotinamide, inhibits, poly(ADP-ribose), polymerase-1, PARP-1, inhibitors, anti-inflammatory, organoids, hematopoietic, haematopoietic, stem, cells, HSC, progenitors, SIRT1, Poly(ADP-ribose), Polymerase, Mesenchymal, Stem, Cells, Organoids, Hematopoietic, Class, III, HDACs, (Sirtuins), 4106, Tocris Bioscience

6 篇 Nicotinamide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nicotinamide 的部分引用包括：

Jun et al (2017) Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell 169 243-257.e25 PMID: 28388409

Thomas C et al (2019) Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity. Cell Stem Cell 25 103-119.e6 PMID: 31155484

Mark R et al (2019) Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway. DNA Repair (Amst) 82 102675 PMID: 31450087

Mihee M et al (2019) Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology. Curr Protoc Pharmacol 85 e54 PMID: 30920154

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Nicotinamide 的评论

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Nicotinamide test.
By Anonymous on 08/21/2024
分析类型： In Vitro
种属： Human
细胞系/组织： pancreatic tumor

We used this reagent for human pancreatic tumor organoid culture by using 10 mM treatment.

review image

Nicotinamide 实验方案

以下实验方案包含使用 Nicotinamide（目录编号 4106）的更多信息。

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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