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Class III HDACs (Sirtuins)

Sirtuins (also known as Silent information regulator (Sir2)-like family deacetylases) are a family of histone deacetylase enzymes. Sirtuins are classified as class III HDACs. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Products
Background
Literature (1)
Gene Data

Class III HDAC (Sirtuin) Inhibitors
Cat. No. Product Name / Activity
4754 AK 7
Selective SIRT2 inhibitor; brain penetrant
7137 Cambinol
SIRT1 and SIRT2 inhibitor
2780 EX 527
Selective SIRT1 inhibitor
4106 Nicotinamide
SIRT1 inhibitor; promotes hematopoietic progenitor proliferation; also PARP-1 inhibitor
5457 SirReal 2
Selective inhibitor of SIRT2
3521 Sirtinol
Selective sirtuin family deacetylase inhibitor

Class III HDAC (Sirtuin) Activators
Cat. No. Product Name / Activity
4590 Honokiol
SIRT3 activator; also blocks NF-κB activation
1418 Resveratrol
SIRT1 activator
7558 SRT 1720
Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis

Related Targets

Sirtuins (also known as Silent information regulator (Sir2)-like family deacetylase) are a family of histone deacetylase enzymes. Sirtuins are classified as class III HDACs. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed. Sirtuins catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis.

In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways.

Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sirtuins are involved in the normal ageing process through their role in resistance to cellular stress.

HDAC classification

Superfamily Family Class Subclass Protein (human)
Arginase/deacetylase superfamily Histone deacetylase family Class I HDAC1, HDAC2, HDAC3, HDAC8
Class II Class IIa HDAC4, HDAC5, HDAC7, HDAC9
ClassIIb HDAC6, HDAC10
Class IV HDAC11
Deoxyhypusine synthase like NAD/FAD-binding domain superfamily Sir2 regulator family Class III I SIRT1, SIRT2, SIRT3
II SIRT4
III SIRT5
IV SIRT6, SIRT7

External sources of pharmacological information for Class III HDACs (Sirtuins) :

    Literature for Class III HDACs (Sirtuins)

    Tocris offers the following scientific literature for Class III HDACs (Sirtuins) to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Rheumatoid Arthritis Poster

    Rheumatoid Arthritis Poster

    Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.

    Sir2-like Family Deacetylase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    SIRT1 Human SIRT1 NM_012238 Q96EB6
    Mouse Sirt1 NM_019812 Q923E4
    Rat Sirt1 NM_001107627 XP_228146
    SIRT2 Human SIRT2 NM_012237 Q8IXJ6
    Mouse Sirt2 NM_022432 Q8VDQ8
    Rat Sirt2 NM_001008368 Q5RJQ4
    SIRT3 Human SIRT3 NM_001017524 Q9NTG7
    Mouse Sirt3 NM_022433 Q8R104
    Rat Sirt3 NM_001106313 XP_215124
    SIRT4 Human SIRT4 NM_012240 Q9Y6E7
    Mouse Sirt4 XM_988059 Q8R216
    Rat Sirt4 NM_001107147 XP_222243
    SIRT5 Human SIRT5 NM_012241 Q9NXA8
    Mouse Sirt5 NM_178848 Q8K2C6
    Rat Sirt5 NM_001004256 Q68FX9
    SIRT6 Human SIRT6 NM_016539 Q9UQD1
    Mouse Sirt6 NM_181586 P59941
    Rat Sirt6 NM_001031649 Q4FZY2
    SIRT7 Human SIRT7 NM_016538 Q9NRC8
    Mouse Sirt7 NM_153056 Q8BKJ9
    Rat Sirt7 NM_001107073 XP_221204