Home / Pharmacology / Enzymes / Histone Deacetylases / Class III HDACs (Sirtuins) / Class III HDAC (Sirtuin) Inhibitors / AK 7

AK 7

Cat. No. 4754 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective SIRT2 inhibitor; brain penetrant
Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AK 7

AK 7 is a selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Compound Libraries for AK 7

AK 7 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AK 7

M. Wt 437.35
Formula C19H21BrN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 420831-40-9
PubChem ID 1328033
InChI Key IYAYHZZWYNXHEQ-UHFFFAOYSA-N
Smiles O=C(NC2=CC(Br)=CC=C2)C1=CC(S(N3CCCCCC3)(=O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AK 7

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.73 100

Preparing Stock Solutions for AK 7

The following data is based on the product molecular weight 437.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.43 mL 22.86 mL
5 mM 0.46 mL 2.29 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for AK 7

References are publications that support the biological activity of the product.

Chopra et al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492 PMID: 23200855

Taylor et al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540 PMID: 21370928

If you know of a relevant reference for AK 7, please let us know.

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1 Citation for AK 7

Citations are publications that use Tocris products. Selected citations for AK 7 include:

Sanjoy et al (2023) SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure. Front Immunol 13 1079962 PMID: 36865524

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Literature in this Area

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.