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Non-selective HDACs

There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is divided into classes I, II and IV. Below are a selection of compounds that target two or more classes of HDACs.

Products
Background
Literature (2)

Non-selective Histone Deacetylase Inhibitors
Cat. No. Product Name / Activity
7981 Belinostat
Potent pan-HDAC inhibitor
6249 Givinostat hydrochloride
Histone deacetylase inhibitor
7629 Panobinostat
Pan-histone deacetylase inhibitor
2682 Sodium 4-Phenylbutyrate
Histone deacetylase inhibitor
4652 SAHA
Class I and II HDAC inhibitor
3850 Sodium butyrate
Histone deacetylase inhibitor
1406 Trichostatin A
Potent histone deacetylase inhibitor
2815 Valproic acid, sodium salt
Histone deacetylase inhibitor

Related Targets

    HDAC classification

    Superfamily Family Class Subclass Protein (human)
    Arginase/deacetylase superfamily Histone deacetylase family Class I HDAC1, HDAC2, HDAC3, HDAC8
    Class II Class IIa HDAC4, HDAC5, HDAC7, HDAC9
    ClassIIb HDAC6, HDAC10
    Class IV HDAC11
    Deoxyhypusine synthase like NAD/FAD-binding domain superfamily Sir2 regulator family Class III I SIRT1, SIRT2, SIRT3
    II SIRT4
    III SIRT5
    IV SIRT6, SIRT7

    External sources of pharmacological information for Non-selective HDACs :

      Literature for Non-selective HDACs

      Tocris offers the following scientific literature for Non-selective HDACs to showcase our products. We invite you to request* your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.

      Epigenetics Scientific Review

      Epigenetics Scientific Review

      Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

      Rheumatoid Arthritis Poster

      Rheumatoid Arthritis Poster

      Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.