Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review1,6-Hexanediol
Description: Tool for probing liquid-liquid phase separation
Purity: ≥98%
Biological Activity for 1,6-Hexanediol
1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.
Technical Data for 1,6-Hexanediol
| M. Wt | 118.18 |
| Formula | C6H14O2 |
| Storage | Store at RT |
| Purity | ≥98% |
| CAS Number | 629-11-8 |
| PubChem ID | 12374 |
| InChI Key | XXMIOPMDWAUFGU-UHFFFAOYSA-N |
| Smiles | OCCCCCCO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 1,6-Hexanediol
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.82 | 100 | |
| DMSO | 11.82 | 100 |
Preparing Stock Solutions for 1,6-Hexanediol
The following data is based on the product molecular weight 118.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.46 mL | 42.31 mL | 84.62 mL |
| 5 mM | 1.69 mL | 8.46 mL | 16.92 mL |
| 10 mM | 0.85 mL | 4.23 mL | 8.46 mL |
| 50 mM | 0.17 mL | 0.85 mL | 1.69 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for 1,6-Hexanediol
References for 1,6-Hexanediol
References are publications that support the biological activity of the product.
Shan et al (2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat.Commun. 9 737 PMID: 29467404
Wheeler et al (2016) Distinct stages in stress granule assembly and disassembly. Elife 5 e18413 PMID: 27602576
Kroschwald et al (2017) Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters
If you know of a relevant reference for 1,6-Hexanediol, please let us know.
View Related Products by Target
Keywords: 1,6-Hexanediol, 1,6-Hexanediol supplier, liquid-liquid, phase, separation, LLPS, liquid-like, solid-like, assemblies, probe, membrane-less, compartments, disrupts, dissolves, Biochemicals, and, Molecular, Biology, 7046, Tocris Bioscience
Citations for 1,6-Hexanediol
Citations are publications that use Tocris products.
Currently there are no citations for 1,6-Hexanediol. Do you know of a great paper that uses 1,6-Hexanediol from Tocris? Please let us know.
Reviews for 1,6-Hexanediol
There are currently no reviews for this product. Be the first to review 1,6-Hexanediol and earn rewards!
Have you used 1,6-Hexanediol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image