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Submit ReviewChromanol 293B
Description: IKs blocker. Also blocks ICFTR
Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for Chromanol 293B
Chromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).
Enantiomer also available.
Compound Libraries for Chromanol 293B
Chromanol 293B is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Chromanol 293B
| M. Wt | 324.39 |
| Formula | C15H20N2O4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 163163-23-3 |
| PubChem ID | 121846 |
| InChI Key | HVSJHHXUORMCGK-UONOGXRCSA-N |
| Smiles | O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Chromanol 293B
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 6.49 | 20 | |
| DMSO | 32.44 | 100 |
Preparing Stock Solutions for Chromanol 293B
The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for Chromanol 293B
References for Chromanol 293B
References are publications that support the biological activity of the product.
Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590 PMID: 11414653
Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007 PMID: 10696102
Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472 PMID: 11332571
If you know of a relevant reference for Chromanol 293B, please let us know.
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Keywords: Chromanol 293B, Chromanol 293B supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B, Voltage-Gated, CFTR, 1412, Tocris Bioscience
5 Citations for Chromanol 293B
Citations are publications that use Tocris products. Selected citations for Chromanol 293B include:
Inagaki et al (2019) Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch 471 313 PMID: 30250967
McCallum et al (2011) The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Mol Pain 15 577 PMID: 20132415
Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Cell Mol Med 9 e96691 PMID: 24798465
Neal et al (2011) Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol 589 3595 PMID: 21576273
Gage and Kobertz (2004) KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol 124 759 PMID: 15572349
Do you know of a great paper that uses Chromanol 293B from Tocris? Please let us know.
Reviews for Chromanol 293B
Average Rating: 5 (Based on 1 Review.)
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Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1.
By
Anonymous on 11/29/2018
Assay Type: In Vitro
Species: Human
Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1. The blocking action exhibited by the product was measured on epithelial Kv2.1 channels.
