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Submit ReviewDeferoxamine mesylate
Description: Iron chelator; also hypoxia mimetic and neuroprotectant
Chemical Name: N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate
Biological Activity for Deferoxamine mesylate
Deferoxamine mesylate is an iron chelator. Also hypoxia mimetic and inhibitor of ferroptosis. Has neuroprotective effects in animal models of stroke, traumatic brain injury and neurodegenerative diseases.
Technical Data for Deferoxamine mesylate
| M. Wt | 656.79 |
| Formula | C25H48N6O8.CH4O3S |
| Storage | Store at -20°C |
| CAS Number | 138-14-7 |
| PubChem ID | 62881 |
| InChI Key | IDDIJAWJANBQLJ-UHFFFAOYSA-N |
| Smiles | ON(C(CCC(NCCCCCN(C(CCC(NCCCCCN(O)C(C)=O)=O)=O)O)=O)=O)CCCCCN.CS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Deferoxamine mesylate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 65.68 | 100 |
Preparing Stock Solutions for Deferoxamine mesylate
The following data is based on the product molecular weight 656.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.52 mL | 7.61 mL | 15.23 mL |
| 5 mM | 0.3 mL | 1.52 mL | 3.05 mL |
| 10 mM | 0.15 mL | 0.76 mL | 1.52 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
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Product Datasheets for Deferoxamine mesylate
References for Deferoxamine mesylate
References are publications that support the biological activity of the product.
Chau et al (2005) Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors. Cancer Res. 65 4918 PMID: 15930314
Kosyakovsky et al (2019) Quantifying intranasally administered deferoxamine in rat brain tissue with mass spectrometry. ACS Chem.Neurosci. 10 4571 PMID: 31573798
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Keywords: Deferoxamine mesylate, Deferoxamine mesylate supplier, iron, metal, chelator, hypoxia, ferroptosis, inhibitors, inhibits, Biochemicals, and, Molecular, Biology, Hypoxia, Inducible, Factors, 5764, Tocris Bioscience
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