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DOPE

Cat. No. 7175 Submit a Review Datasheet / COA / SDS
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Description: Liposome/lipoplex transfection enhancer
Chemical Name: (9Z)-1,1'-[(1R)-1-[[[(2-Aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] 9-octadecenoic acid ester
Purity: ≥95% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DOPE

DOPE is a liposome/lipoplex transfection reagent. Enhances liposome and lipoplex transfection efficiency in combination with DA, DOTAP or DC-cholesterol (Cat. No. 7176).

Please note: exact ratio for use and transfection efficiency is dependent on cell line used.

Technical Data for DOPE

M. Wt 744.05
Formula C41H78NO8P
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 4004-05-1
PubChem ID 9546757
InChI Key MWRBNPKJOOWZPW-NYVOMTAGSA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](CO[P](O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DOPE

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
chloroform 74.4 100

Preparing Stock Solutions for DOPE

The following data is based on the product molecular weight 744.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.72 mL 13.44 mL
5 mM 0.27 mL 1.34 mL 2.69 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for DOPE

References are publications that support the biological activity of the product.

Mochizuki et al (2013) The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine. Biochim.Biophys.Acta. 1828 412 PMID: 23092705

Kim et al (2015) DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes. Biochim.Biophys.Acta. 1848 1996 PMID: 26112463

If you know of a relevant reference for DOPE, please let us know.

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Citations for DOPE

Citations are publications that use Tocris products.

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