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Submit ReviewDynapyrazole A
Description: Hedgehog signaling inhibitor; dynein inhibitor
Chemical Name: 2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile
Purity: ≥98% (HPLC)
Biological Activity for Dynapyrazole A
Dynapyrazole A is a dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC50 values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC50 = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.
Compound Libraries for Dynapyrazole A
Dynapyrazole A is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Dynapyrazole A
| M. Wt | 486.7 |
| Formula | C20H12ClIN4O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2226517-75-3 |
| PubChem ID | 136213044 |
| InChI Key | VABPBCMFKJDOHP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2(C3=NN4C(NC(C5=CC(I)=CC=C45)=O)=C3C#N)CC2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Dynapyrazole A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.73 | 20 |
Preparing Stock Solutions for Dynapyrazole A
The following data is based on the product molecular weight 486.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.27 mL | 51.37 mL | 102.73 mL |
| 1 mM | 2.05 mL | 10.27 mL | 20.55 mL |
| 2 mM | 1.03 mL | 5.14 mL | 10.27 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
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Product Datasheets for Dynapyrazole A
References for Dynapyrazole A
References are publications that support the biological activity of the product.
Steinman et al (2017) Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife 6 e25174 PMID: 28524820
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Keywords: Dynapyrazole A, Dynapyrazole A supplier, dynein, inhibitors, inhibits, hedgehog, signaling, flagellar, transport, retrograde, anterograde, Hedgehog, Signaling, 6896, Tocris Bioscience
Citations for Dynapyrazole A
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