Home / Pharmacology / Enzymes / Kinases / Casein Kinase 1 / Casein Kinase 1 Inhibitors / Epiblastin A

Epiblastin A

Cat. No. 6340 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
Chemical Name: 6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Epiblastin A

Epiblastin A is a CK1 inhibitor (IC50 values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.

Compound Libraries for Epiblastin A

Epiblastin A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Epiblastin A

M. Wt 287.71
Formula C12H10CIN7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 16470-02-3
PubChem ID 118987042
InChI Key ZWNKKZSRANLVEW-UHFFFAOYSA-N
Smiles NC1=NC2=NC(N)=C(C3=CC(Cl)=CC=C3)N=C2C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Epiblastin A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.75 20

Preparing Stock Solutions for Epiblastin A

The following data is based on the product molecular weight 287.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.38 mL 86.89 mL 173.79 mL
1 mM 3.48 mL 17.38 mL 34.76 mL
2 mM 1.74 mL 8.69 mL 17.38 mL
10 mM 0.35 mL 1.74 mL 3.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Epiblastin A

References are publications that support the biological activity of the product.

Illich et al (2016) Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 15 787 PMID: 27149845

Ursu et al (2016) Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 23 494 PMID: 27049670

If you know of a relevant reference for Epiblastin A, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Casein Kinase 1 Inhibitors

Keywords: Epiblastin A, Epiblastin A supplier, EpiblastinA, CK1, inhibitors, inhibits, casein, kinase, Epiblast, stem, cells, conversion, pluripotency, self, renewal, Casein, Kinase, 1, Stem, Cell, Proliferation, Reprogramming, 6340, Tocris Bioscience

Citations for Epiblastin A

Citations are publications that use Tocris products.

Currently there are no citations for Epiblastin A. Do you know of a great paper that uses Epiblastin A from Tocris? Please let us know.

Reviews for Epiblastin A

There are currently no reviews for this product. Be the first to review Epiblastin A and earn rewards!

Have you used Epiblastin A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets