Home / Pharmacology / Enzymes / Kinases / Casein Kinase 1 / Casein Kinase 1 Inhibitors / PF 5006739

PF 5006739

Cat. No. 6346 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent CK1δ/ε inhibitor
Chemical Name: 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PF 5006739

PF 5006739 is a potent casein kinase 1δ/ε inhibitor (IC50 values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behavior in addiction in vivo models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 5006739

PF 5006739 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 5006739

M. Wt 419.46
Formula C22H22FN7O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1293395-67-1
PubChem ID 51353555
InChI Key XPWHRQHBPRSUAW-UHFFFAOYSA-N
Smiles NC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 5006739

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.95 100

Preparing Stock Solutions for PF 5006739

The following data is based on the product molecular weight 419.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for PF 5006739

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for PF 5006739

References are publications that support the biological activity of the product.

Wager et al (2014) Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 5 1253 PMID: 25299732

If you know of a relevant reference for PF 5006739, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Casein Kinase 1 Inhibitors

Keywords: PF 5006739, PF 5006739 supplier, PF5006739, Casesin, kinase, 1δ/ε, delta, epsilon, inhibitors, inhibits, circadian, rhythm, opioid, drug, seeking, behaviour, addiction, Casein, Kinase, 1, 6346, Tocris Bioscience

Citations for PF 5006739

Citations are publications that use Tocris products.

Currently there are no citations for PF 5006739. Do you know of a great paper that uses PF 5006739 from Tocris? Please let us know.

Reviews for PF 5006739

There are currently no reviews for this product. Be the first to review PF 5006739 and earn rewards!

Have you used PF 5006739?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets