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TAK 715

Cat. No. 4254 Submit a Review Datasheet / COA / SDS
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Description: Potent p38 MAPK inhibitor; anti-inflammatory
Chemical Name: N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TAK 715

TAK 715 is an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Compound Libraries for TAK 715

TAK 715 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TAK 715

M. Wt 399.51
Formula C24H21N3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 303162-79-0
PubChem ID 90488922
InChI Key BRYAJHADJWBFQY-UHFFFAOYSA-N
Smiles CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAK 715

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.95 100
ethanol 19.98 50

Preparing Stock Solutions for TAK 715

The following data is based on the product molecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for TAK 715

References are publications that support the biological activity of the product.

Miwatashi et al (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 48 5966 PMID: 16162000

Verkaar et al (2011) Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 18 485 PMID: 21513885

If you know of a relevant reference for TAK 715, please let us know.

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Keywords: TAK 715, TAK 715 supplier, TAK715, p38, MAPK, inhibitors, Mitogen-activated, protein, kinase, anti-inflammatory, inhibits, wnt, b-catenin, inhibitor, beta-catenin, casein, Casein, Kinase, 1, Beta-catenin, 4254, Tocris Bioscience

Citations for TAK 715

Citations are publications that use Tocris products.

Currently there are no citations for TAK 715. Do you know of a great paper that uses TAK 715 from Tocris? Please let us know.

Reviews for TAK 715

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for TAK 715

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.