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Submit ReviewTAT-Gap19
Description: Cx43 hemichannel blocker
Purity: ≥95% (HPLC)
Biological Activity for TAT-Gap19
TAT-Gap19 is a Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.
Technical Data for TAT-Gap19
| M. Wt | 2703.28 |
| Formula | C119H212N46O26 |
| Sequence | YGRKKRRQRRRKQIEIKKFK |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1507930-54-2 |
| PubChem ID | 127021051 |
| InChI Key | ALNCFPIRTLVJPY-XELKYWHDNA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAT-Gap19
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for TAT-Gap19
References for TAT-Gap19
References are publications that support the biological activity of the product.
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID: 25374505
Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID: 25913636
If you know of a relevant reference for TAT-Gap19, please let us know.
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Keywords: TAT-Gap19, TAT-Gap19 supplier, Inhibitors, Inhibits, connexin43, Cx43, Brain, penetrant, Cell, permeable, Gap, Channels, 6227, Tocris Bioscience
2 Citations for TAT-Gap19
Citations are publications that use Tocris products. Selected citations for TAT-Gap19 include:
Wei et al (2020) Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling. J Neuroinflammation 17 322 PMID: 33115476
Matthias M et al (2020) Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins. Development 147 PMID: 32541014
Do you know of a great paper that uses TAT-Gap19 from Tocris? Please let us know.
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